Nattokinase Minus Vitamin K (Vitamin K1, the clotting vitamin) is an all-natural systemic enzyme that is extracted from highly purified Japanese natto. Systemic enzymes are to be taken on an empty stomach. Systemic enzymes support cleaning out debris in the arteries. Research indicates that nattokinase may support healthy blood flow as well as aid in successfully breaking down fibrin, a blood clotting protein. Nattokinase Minus Vitamin K contains NSK-SD® and is the highest activity (20,000 fibrin units per gram) nattokinase produced. U.S. patented manufacturing process, patent application #20010046697 removes Vitamin K to prevent adverse interactions with warfarin. Caution: This product is contraindicated for individuals with a history of bleeding or with conditions associated with bleeding. Use only under the supervision of your healthcare practitioner, especially if taking anticoagulant or blood pressure medications. Directions: Take one capsule twice daily on an empty stomach or as directed by your healthcare practitioner.